Structure-activity relationship study on Asian natural products for differentiation of ES/iPS cells

Project Leader:
Professor
Nakao KOJIMA
Faculty of Pharmacy

Reprogramming technology has made it possible to induce somatic cells into pluripotent stem cells (iPS cells). This technology has opened the new gateway for a regenerative therapy, which is critical for degenerative diseases such as Alzheimer’s disease and Parkinson’s disease. However, further challenges are still required to control lineage-specific differentiation. Recently, it has been reported that some small molecules are able to induce differentiation of ES/iPS cells. Therefore, it is important to construct a chemical library containing ES/iPS cells differentiation-inducible compounds. This project is planned to identify Asian natural products for the differentiation (especially for neural differentiation) of ES/iPS cells and to elucidate the structure-activity relationship.






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