Development of animal models for schizophrenia and Alzheimer disease and application of oriental traditional medicines to these diseases

Project Leader:
Toshitaka NABESHIMA
Faculty of Pharmacy

Schizophrenia and Alzheimer disease are two representatives of typical psychiatric disorders, and patients are increasing world wide. In order to evaluate the candidate drugs for them, we have been developed animal models. Mice that received phencyclidine repeatedly show not only positive symptoms, but also cognitive deficits and negative symptom-like behaviors of schizophrenia. An Alzheimer diseased animal model produced by injection of amyloid ?-peptide into the cerebral ventricle shows impairment of memory and neuronal function. In this project, Chinese, Korean and Japanese members collaborate to improve these animal models and to evaluate the therapeutic and/or preventive drugs from oriental traditional medicines using these animal models.










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